I've run it on all my desktop and laptop computers for 20 years and it's fine. However, the only package I upgrade automatically is Chrome. I do a full upgrade one or twice a year, and in the meantime I only upgrade packages as needed. The whole point of versioned dependencies is that you don't have to adhere to one particular snapshot.

Automatically upgrading every day is not smart, since then you're virtually guaranteed to catch every breaking change. See https://wiki.debian.org/DebianUnstable#What_are_some_best_pr...