Yes, and (for example) Fastmail allows you to do that very easily. So does Google if you prefer to keep the Gmail interface & are willing to pay for G Suite.
And, if your mail client’s UI allows, you can even send from <whatever>@yourdoma.in to avoid disclosing your “real” address when you reply.
My favorite use-case: you sign up for foo.com with foo@yourdomain.com. Then foo sells their contact database, and now you’re getting viagra spam all day. Ok, just add a filter to auto-trash anything addressed to foo@, and the problem is solved.
And, if your mail client’s UI allows, you can even send from <whatever>@yourdoma.in to avoid disclosing your “real” address when you reply.
My favorite use-case: you sign up for foo.com with foo@yourdomain.com. Then foo sells their contact database, and now you’re getting viagra spam all day. Ok, just add a filter to auto-trash anything addressed to foo@, and the problem is solved.