For me it's Kratom. It's helped me out of deep depression and also does more to help with migraines than any painkiller I've tried. I've been using it regularly for about 5 years now (with occasional cycles to reduce tolerance). So far, I have found no downsides except for the taste. When I stop taking it, there's one day of grumpiness which I would say it of similar strength to effect of stopping coffee after a regular habit.

(EDIT because I'm not allowed to make a new comment for some reason, this is a reply to the comment below)

Every person is different and you must take care of what you put in your body. I take kratom because it's a double whammy that reduces two problems - depression and migraine - to manageable levels, while having low potential for addiction. I have so far encountered no negative effects from taking it, only positives.

However, I would prefer _not_ to take it. I would prefer _not_ to have depression and migraines and not to need any drugs to maintain a normal lifestyle.

I work on this by maintaining a healthy diet, exercising regularly, sleeping well, meditation, and maybe I'll get there someday. In the meantime, kratom has increased my quality of life a lot over the past few years. This is not intended as a suggestion that anyone else should take it, just an anecdote about my experience.

Regarding constipation - I have heard this before, but never personally experienced it. I mix each dose (<1tps) with a full cup of water, which probably helps.

I don't want to talk about it, but people should be wary of kratom, went to some bad places with it.

Also at minimum constipation is a massive symptom

Yeah, it's not a wonder drug. There are serious risks. And in terms of treatment for something like depression, it should be regarded like any other depression treatment: it may work for some and be crap for others, and do awful things to some people. If you have access to quality professional mental health care, that should be your first stop, before self-educating.