It also depends to some extent on whether you count interpretations as "within" mathematics. For example, Stephen Hawking's latest book clearly draws on a lot of mathematical models of the universe, but its main arguments are non-mathematized, philosophical ones. Arguably they're arguments over how to interpret the existing mathematical models (though some stray further from math than others), but the arguments themselves appear to live outside what you'd normally call mathematics.
Interpretations of quantum mechanics fall into a similar camp. There is the actual formal theory of quantum mechanics, which is clearly mathematics; but something like the Copenhagen Interpretation is also attempting to "describe" the universe, but is forced to do it extra-mathematically, by attaching interpretations (which can't be mathematically proven) to the formal results.
I suppose it also depends on what one means by "describe": does quantum mechanics fully "describe" the universe, or is it quantum mechanics plus an interpretation which describes the universe?
The jury is still out on that one.