It's not a matter of "just learn WebAssembly", nobody (with some exceptions to those working on tooling) is going to learn raw WebAssembly, it just won't happen.

I would suggest that Blazor (C#) and Yew (Rust) are probably two of the most usable frameworks currently. There are some commercial libraries for Blazor and even some open source, but more is needed. There are ongoing and breaking changes that will be painful if you start adopting now.

Beyond all of this, is the fact that you still are interacting with the DOM via a transport layer that will generally not be great for a lot of use cases, you might do well with a canvas and animation frame events, but that won't have good accessibility.

Even then we're talking about native applications for portable devices, which likely won't see a good WASM story for a few years and in the case of Apple, if ever.

I'm not saying that WASM isn't cool... it really is, and you can do some very cool things with it as a target both browser and in dedicated runtimes... it's just not ready/baked for application targets (yet), and you shouldn't be betting a startup, or long-lived application on it just yet.