"Apocynin was first described by Oswald Schmiedeberg, a German pharmacologist, in 1883 and was first isolated by Horace Finnemore,[1] in 1908, from the root of Canadian hemp (Apocynum cannabinum).[2] At the time, this plant was already used for its known effectiveness against edema and heart problems."
"Apocynum cannabinum (dogbane, amy root, hemp dogbane, prairie dogbane, Indian hemp, rheumatism root, or wild cotton)[2] is a perennial herbaceous plant that grows throughout much of North America - in the southern half of Canada and throughout the United States.[1][3] It is a poisonous plant: Apocynum means "poisonous to dogs". All parts of the plant are poisonous and can cause cardiac arrest if ingested."
...
"Apocynum cannabinum was much employed by various Native American tribes who used it to treat a wide variety of complaints including rheumatism, coughs, pox, whooping cough, asthma, internal parasites, diarrhoea and also to increase milk flow in lactating mothers.[6] The root has been used as a tonic, cardiotonic, diaphoretic, diuretic, emetic (induces vomitting) and expectorant.[9][6] It is harvested in the autumn and dried for later use. The fresh root is the most active part medicinally."
And it seems to be one of the medicinal plants that the north American locals have known about long before Europeans rocked up.
"Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors3. Y27632 in combination with Pifithrin-u significantly improves cell recovery after cryopreservation"
Does anybody here know what the similarities are likely to be between those two compounds and if Apocynum has already being used dermatalogically? Given the history it seems very unlikey that it wouldnt have already been made into a topical skin cream by someone before now. I'm also guessing that the people who make Y27632 are going to be cranking up production right about now and giggling a lot.
"We selected candidate chemicals that potentially increased the stem cell property [Apocynin] or reduced production of reactive oxygen species [Y-27632]"
Thanks. I find it interesting that they are reporting success hitting two apparently seperate trigger mechanisms of the same process in the same study. I wonder how this will hold up in further studies as this seems kinda lucky.
Was chatting about this with someone on Health News. I doubt it's lucky - the two compounds have been examined together in several previous studies; https://www.nature.com/articles/hr2005119
Search for Apocynin first...
https://en.wikipedia.org/wiki/Apocynin
"Apocynin was first described by Oswald Schmiedeberg, a German pharmacologist, in 1883 and was first isolated by Horace Finnemore,[1] in 1908, from the root of Canadian hemp (Apocynum cannabinum).[2] At the time, this plant was already used for its known effectiveness against edema and heart problems."
https://en.wikipedia.org/wiki/Apocynum_cannabinum
"Apocynum cannabinum (dogbane, amy root, hemp dogbane, prairie dogbane, Indian hemp, rheumatism root, or wild cotton)[2] is a perennial herbaceous plant that grows throughout much of North America - in the southern half of Canada and throughout the United States.[1][3] It is a poisonous plant: Apocynum means "poisonous to dogs". All parts of the plant are poisonous and can cause cardiac arrest if ingested."
...
"Apocynum cannabinum was much employed by various Native American tribes who used it to treat a wide variety of complaints including rheumatism, coughs, pox, whooping cough, asthma, internal parasites, diarrhoea and also to increase milk flow in lactating mothers.[6] The root has been used as a tonic, cardiotonic, diaphoretic, diuretic, emetic (induces vomitting) and expectorant.[9][6] It is harvested in the autumn and dried for later use. The fresh root is the most active part medicinally."
And it seems to be one of the medicinal plants that the north American locals have known about long before Europeans rocked up.
Then if I search for Y27632, I get stuff like;
https://www.reprocell.com/small-molecules-c1/stemolecule-y27...
"Y27632 is a cell-permeable small molecule Rho-associated kinase (ROCK) inhibitor1. Y27632 has been found to prevent apoptosis as well as enhance the survival and cloning efficiency of dissociated human embryonic stem (ES) cells without affecting their self-renewal properties or pluripotency2. This molecule has also been shown to enhance survival during the transplantation of ES cell-derived neural precursors3. Y27632 in combination with Pifithrin-u significantly improves cell recovery after cryopreservation"
Does anybody here know what the similarities are likely to be between those two compounds and if Apocynum has already being used dermatalogically? Given the history it seems very unlikey that it wouldnt have already been made into a topical skin cream by someone before now. I'm also guessing that the people who make Y27632 are going to be cranking up production right about now and giggling a lot.