Two questions: can't large files continue to be served on HTTP2? and won't https://www.dpdk.org/ allow user-space network stacks to do segmentation, etc...? (Maybe it's too immature?)
Even HTTP/2 involves some of the issues the parent mentions. HTTP/2 is not really helpful for large files, and might likely perform worse than HTTP/1.1 due to the additional insertion and parsing of control flow headers. HTTP/2 helps small files most, by avoiding the overhead of connection establishment for those.