There's some anectotal evidence for pre-Younger Dryas civilizations, such as various peoples' myths regarding previous golden ages ended by terrible floods and so on, as well as some early civilizations using techniques and doing stuff that seems impossible to us.

If there was a relatively advanced civilization somewhere in the area, a meteor strike and subsequent climate instability could definitely have brought it down. Ice sheets could easily have crushed any cities in the northern hemisphere without leaving much trace except from the oral traditions of more primitive peoples who managed to survive.

Problem is, that without solid evidence it's just guesswork.