So you're basically building a distributed application just because you can't share memory properly. This can be very efficient if little communication is involved or a total nightmare if you have gigabytes of data where you need lots of random read access to walk the data structures at high speed. If you're not careful you spend most of your time pickling and unpickling the stuff you send over your pipes while requiring duplication of your gigabyte data structures in order to gain at least some parallelism.

I don't see a way around this mess with the current structure of python. You would have to reimplement the data heavy part completely in another language that provides proper threading models.