Being acquired isn't necessarily a negative, but all too often the next step after being acquired is "Hi, we've been acquired and this service is shutting down." (With a nod that they'll be back, and better than ever. Which generally doesn't turn out to be true.)
I'm generalizing here, but when someone decides to build a startup, it's usually because there is a problem that they want to solve so desperately that they're willing to forgo the comforts of a regular paycheck and having to only concentrate on one or two things a day. They're willing to endure sleepless nights, stress, uncertainty, and pour a huge amount of effort into creating something.
So, they tend to take care of their customers really well. They tend to produce the best product or service they can, and if they succeed at that, they become really popular.
Established large businesses have completely different priorities. Oracle's licensing schemes for one example are not designed for their customers' benefit; they're designed to maximize Oracle's profit, calculated in part by how many customers they can afford to lose.
In Backblaze's case, let's look at their business model: $5/month for unlimited storage per computer. This is great for their customers. It solves an important problem. They even mentioned in this post that they set out to create this service after one of their friends suffered an agonizing data loss.
But, that's not the most profitable way to run the business. Oracle for example would make a lot more money on it by offering it to their enterprise customers at some absurd monthly fee (plus fees for an annual support contract), and ignore the consumer market altogether, along with all of the headaches that comes from the additional data storage and support costs for supporting the consumer market.
So yeah, I'm not usually too excited by the news that some really great startup is looking to get acquired.
