According to the SSG website, Autodesk Maya will fully support the SSG, including the 2TB memory.
"ProRender plug-in for Maya has full support for the out-of-core rendering feature found on the Radeon™ Pro SSG which allows the application to tap into the full 2TB of memory found locally on the card. This allows users with very large models to render fully accelerated by the GPU. "
The fact that "2TB is addressable" is irrelevant. Putting NAND on the board doesn't improve latency/bandwidth nearly enough to function like vram. Nvidia has also supported unified virtual memory since Pascal, meaning you can address your cpu's ram in GPU code. The "SSG" card still has the 2tb of flash on a PCIe interface, so not much difference from existing systems beyond marketing. I'd expect very few real world perf wins.
Surprised the Radeon Pro SSG isn't an option. It's basically the WX 9100 with 2TB of flash memory slapped on that you can use as VRAM:
https://pro.radeon.com/en/product/pro-series/radeon-pro-ssg/