"According to court testimony, Pickard's lab produced up to a kilogram of LSD approximately every five weeks for short periods. Despite criticism for their methodology, the DEA contends that following their arrest there was a 95% drop in the availability of LSD in the US in the two years following the arrest.[1] Pickard himself has long denied these claims. In his 2007 paper "International LSD Prevalence — Factors Affecting Proliferation and Control", Pickard suggests that since the 1960s LSD production has always been de-centralized. As to a turn-of-the-century decline in availability due to his own arrest, Pickard highlights the fact that LSD availability had been on the decline since 1996, a fact which he correlates in part with the exponential growth of availability and demand for MDMA and other hallucinogenic drugs.[8] The actual quantity of LSD seized by the DEA remains unclear, with figures ranging from 198.9 grams to 41.3 kilograms."

https://en.wikipedia.org/wiki/William_Leonard_Pickard