>Uncanny valley, not trying at all looks a lot better than trying hard and being slightly off.
Nice counter-argument, but I'd still say no. There are still tons of sites that try but are still off, and people don't care at all, they're still huge.
It's all about the service, unless one's is catering to OCD customers.
And besides, Craigslist and Drudge Report don't look nice, but they still look aligned in the places where they're trying.