Replying to myself to add an additional point: Lague's cave system doesn't try to avoid designs with back-tracking -- in fact because he joins the orphaned spaces to the main space, the resulting cave system has more dead-end caves in it.

But that said, during the creation process one could easily track these spaces-that-were-previously-orphaned, and could easily use that list to spawn specials in these rooms (e.g. make the dead-end caves into features instead of bugs, by placing goals/treasure/sub-bosses/etc in them)