I don't think the OP was saying that - they were saying that it's not a technically difficult issue, and they would be fairly right.
In my experience, most large fashion sites can comfortably run on a Magento instance with a fairly simple architecture, normally a small handful of load balanced PHP instances, with a dual read slave / master database configuration.
Fashion itself, however, is a much different beast, being cool, hip, whatever, it takes a lot of skill - to really understand your target market and sell them something they don't even know they want yet.
Source: I'm a software engineer who has previously worked for www.missguided.co.uk, www.jdsports.co.uk, www.boohoo.com and currently works for www.countryattire.co.uk