I read somewhere that the one thing all the startup hubs had in common was that they were a desirable place to live. This does not seem to describe just about anywhere in the mid-west with its bad climate and shrinking cities.
Maybe that info is stale? Climate isn't perfect but cities are not shrinking. There are 200M more Americans these days; they don't all live on the coast. Many midwest cities are growing. Slowly with reasonable housing costs.