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Well well… had no idea this was going on a few miles from me.


>>Can these 22% be identified based on some criteria?

Usually the preferred approach in cases like this is to trial the medication and revert back to the prior treatment plan if symptoms worsen. Obviously, this is only viable if the worst-case negative outcome is temporary, easily reversible, and not life threatening.


I miss the sense of possibility, anarchy, and resistance of the early internet. RIP.


Michael Moore did something very close to this in the mid-90s for his briefly-lived TV Nation. Parked a series of cars in front of the home of a car alarm company CEO and set them off.


My priors include none of the agencies having expertise in epidemiology.


You are wrong, something that you could have easily checked yourself. There are many sophisticated epidemiology groups throughout defense and intelligence. It is a longstanding critical part of their mission, for a variety of end purposes.


While I am very skeptical of the lab leak hypothesis as an infectious disease epidemiologist, the DoE has a fair amount of expertise via the national labs.


Can you please share the reasons why you are skeptical?


A few reasons, though as I note in another comment, I'm not an expert in spillover events, my area of interest kicks in about a week later. So there's a few:

1) People I trust are skeptical, including people who are opposed to gain of function research. I've found Angela Rasmussen to be one of the better voices in terms of discussing the evidence for a natural origin, but she's far from the only one.

2) We have had two naturally occurring coronavirus epidemics during my career. A third is all but inevitable -- I wrote a grant in October 2019 suggesting a novel coronavirus as an example case for a modeling exercise, for example (sadly, said grant didn't get funded). So for me, there's a very strong prior on coronaviruses emerging as significant public health threats.

3) At the same time, I've come to distrust many of the voices who push the lab leak hypothesis, either because they're obviously doing so for geopolitical reasons, or because they've become addicted to being "the lone voice in the wilderness", despite it not being a risky position to take.

4) The lab leak hypothesis, in terms of evidence, relies on WIV, the Chinese Government, the WHO, etc. being broadly incompetent except when it comes to the characterization of the initial cases when SARS-CoV-2 emerged, which is arguably the hardest part of any outbreak.


> or because they've become addicted to being "the lone voice in the wilderness", despite it not being a risky position to take.

This frankly makes me distrust you; in 2020-2022 this was absolutely a risky position to take for most public figures, let alone those on academia, let alone those connected to epidemiology. This remains the only time and topic I've seen blanket banned from discussing across all major US social platforms. Try looking up what the vibe was like in 2020-2021 especially.


I got death threats for suggesting that mandatory vaccination for school kids wasn't well justified not from the people who wanted vaccination, but from the people who decided I wasn't sufficiently opposed to it.


That's obviously bad. Vaccination and COVID origins are different topics, though.

Opinions do correlate in the general public, and I guess that's why you've made that link. I don't think that trend holds among scientists, though--Deigin, Chan, Ebright, Bloom, etc. all have quite ordinary views on vaccine risk and efficacy.


Lol people were getting called racist for suggesting it was anything less than the spawn of a bat and an asian water racoon.

It still isn't even acceptable to acknowledge the (blatant) possibility that Omnicron was intentionally leaked because of low vaccine effectiveness.


Let's be honest, if their is a global conspiracy to spread disease I think it's to kill off the masses due to AI replacing jobs and lowering the amount of green houses gasses people produce.


Can you elaborate on point 4? Your comment is interesting but I don't entirely follow.


Basically, things like "It started in Wuhan near the WIV" implies that we actually have found the first case, etc., when this is notoriously difficult to do, especially with a disease that can have mild or asymptomatic presentation.


I agree with that statement. Even with prior warning, and knowing the virus could be introduced only at an airport or seaport, Western public health authorities managed to trace approximately zero cases to their introduction. So it's hard to believe the same tools would succeed at the much more difficult task of tracing the very first cases in China.

That makes it odd that you're promoting an author who has claimed such evidence shows conclusively that spillover into humans--and not just a super-spreader event--occurred in the Huanan Seafood Market. I suspect that if you looked personally at the methodology behind the conflicted (Rasmussen's doctorate was under Vincent Racaniello, a longtime proponent of high-risk virological research) authors' claims, then you'd find them much less worthy of repetition.


I think her arguments are solid, I'm just not certain they're definitive. But I do find her presentation of those arguments to be both detailed and accessible.


You might not be certain they're definitive, but she is:

> There’s really no explanation other than that the virus started spreading in the human population at that market

https://www.theguardian.com/world/2022/aug/13/angela-rasmuss...

The claim that the location of spillover can be definitively localized within hundreds of meters from epidemiological data is core to the predominant theory of natural zoonotic origin, from an overlapping set of authors including Rasmussen.

Theories of a research accident almost never assume such localization is possible, not least because the earliest known cases weren't particularly close to the WIV. (If anyone's claiming otherwise, they've probably confused the WIV and Wuhan CDC.) So it's odd that you'd correctly note the near-impossibility of that localization, but then cite that as evidence against unnatural origin.

This makes me think you haven't looked much in the details yourself, and two of your four points above are explicitly arguments from authority. If you did look yourself, then I think your assessment might change.


Doesn't the same difficulty of finding the first case also apply to the wet market theory?


Indeed, so it could be some unidentified third place. There are few labs and many other possibilities for people to come into contact with animals, so that third place was probably not a lab.


Yep.

My prior is that it is a zoonotic spillover event. Not necessarily that one, though there is some good evidence for it.


If you followed events at the time and the suppressed rumours from doctors in China end of 2019, the new illness began exactly around that area actually (https://en.wikipedia.org/wiki/Li_Wenliang etc).

There were no similar reports in another place on this planet. (Since 99% of other places do not have full control of media and many have better healthcare so if it happened it would be less likely to go unnoticed)


There was similar report about sudden increase of cases of atypical pneumonia at Oct 16, 2019 in Krasnoyark Krai, Siberia, Russia: about 700 cases per week, which is similar to Covid-19 levels.


The main database of samples and viral sequences of the Wuhan Institute of Virology went offline on Sep 12th 2019.


Satellite images of Wuhan may suggest coronavirus was spreading as early as August 2019:

https://www.bbc.com/news/world-us-canada-52975934.amp

https://edition.cnn.com/2020/06/08/health/satellite-pics-cor...


Would it mean it was active earlier but a critical mass was needed to cause a pandemic? Or it evolved in humans while circulating Wuhan?


That's a smoking gun. And next month it was likely already circulating in Wuhan (https://www.reuters.com/world/china/first-covid-19-case-coul...), coincidence.

> A joint study published by China and the World Health Organization at the end of March acknowledged there could have been sporadic human infections before the Wuhan outbreak.


No, it doesn't. Quote from the article:

> Researchers from Britain's University of Kent used methods from conservation science to estimate that SARS-CoV-2 first appeared from early October to mid-November 2019, according to a paper published in the PLOS Pathogens journal.


>no similar reports

Covid detected in wastewater samples

December 2019 in Italy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428442/

>November 2019 in Brazil: https://www.medrxiv.org/content/10.1101/2020.06.26.20140731v...

They found covid in samples of the sewage system in SC state Brazil in November. 2 months before it came out of wuhan

https://www.cnnbrasil.com.br/saude/novo-coronavirus-ja-estav...

>March 2019 in Spain: https://www.medrxiv.org/content/10.1101/2020.06.13.20129627v...

Brazil recorded its first COVID death April 15, 2019. Initially taken as a data entry error by some, data for 2019 is still published nearly six years after the fact.

https://transparencia.registrocivil.org.br/dados-covid-downl...


Spain paper was not peer-reviewed.

November Brazil could happen because December is when rumours already circulated in China and October is when it was out in Wuhan already per your link.

April Brazil I don't know what to tell you, no sources support the wild claim that it was NOT a data error.

> 2 months before it came out of wuhan

Source? I bet it came out earlier. It was circulating in Wuhan before the pandemic according to WHO. Just people in China who are more likely to get infected are less likely to travel abroad (social class/sanitary conditions/etc) but maybe one person brought it out.


I believe these agencies may have other kinds of intelligence data such as satellite photos of the (empty?) Wuhan Institute of Virology carpark, spikes in mobile phone activity in the area etc. So assessments are made on more than just biological principles.


The hospital was full.

The institute would never be full.

There is no "bring your child to work day" in China.

Weird conflation, unlikely... uunless you mean to muddy the waters and sow dis-information.


I would argue you are sowing disinfo and I honestly dont know what point you are trying to make. Spikes and/or significant reductions in activity as indicated by external data sources, and particular the timing thereof, will obviously be very useful for determining the sequence of events.


The hospital, sure.

Why would Wuhan center being empty represent anything?

People don't rush to a random (unrelated) building when they get sick at the "market".

Coincidence, surely?

What are the chances of having a specialized infectious disease center next to where that type of disease spontaneously emerged?

More or less likely than a bat having sex with a panda possum?

No one, not even the cowardly academics, believed it.


Is Rasmussen really in favour of a GoF ban and destroying the academic value of the background of the majority of her professional friends in the field? Cause I can't really find her calling for a ban, quite the opposite really.

This is the problem with virology, it IS GoF. Expecting virologists to be objective in this is expecting the impossible, like expecting the WHO to apologize for sending Daszak as head of the fact finding mission. They were either THAT incompetent or THAT self interested in maintaing GoF/virology, damn the truth.

I suspect virologists still see themselves as guards on the wall and that we can't handle the truth. Which we already know from the early emails is how they thought early on, why should I assume their propensity for dishonesty has changed?


The virus evolved in an AIDS patient.


“as an infectious disease epidemiologist”

Yet you propose no thoughts of your own. You only base it on your belief in people around you and your disbelief of people you assume are political. This sounds not scientific at all. Are you really an epidemiologist?

I was honestly hoping for more given that you’re supposedly an epidemiologist.


I base it on my evaluation of the arguments of those people as an epidemiologist. And their expertise - as I've said, my expertise focuses on a different aspect of outbreaks, with its own theories and methods, and I know enough to recognize that addressing this requires a good deal of specialized knowledge.


Well, that sounds more reasonable, but the prior comment seems to be relying mostly on reputation and political viewpoints rather than the arguments themselves.


My priors include all the agencies (the Intelligence Community, arguably the deep state) having ulterior political and personal motives. Does noone remember the Iraqi Weapons of Mass Destruction hoax that the CIA cooked up for GWB?

I would not trust any of these agencies to provide objective findings or conclusions, there is a lot of power on the table that's at stake.


The CIA did not cook up the Iraqi Weapons of Mass Destruction hoax. Paul Wolfowitz had to create an entirely new intelligence agency with hand-picked analysts to get that result, because the existing agencies refused to make that claim.

https://en.wikipedia.org/wiki/Office_of_Special_Plans


According to Iraq general, WMD were moved to Syria about 6 month prior to invasion, then Syrian government used them against rebels.

HANNITY: So he had them.

SADA: Yes.

HANNITY: Where were they? And were they moved and where?

SADA: Well, up to the year 2002, 2002, in summer, they were in Iraq. And after that, when Saddam realized that the inspectors are coming on the first of November and the Americans are coming, so he took the advantage of a natural disaster happened in Syria, a dam was broken. So he — he announced to the world that he is going to make an air bridge...

HANNITY: You know for a fact he moved these weapons to Syria?

SADA: Yes.

HANNITY: How do you know that?

SADA: I know it because I have got the captains of the Iraqi airway that were my friends, and they told me these weapons of mass destruction had been moved to Syria.

BECKEL: How did he move them, general? How were they moved?

SADA: They were moved by air and by ground, 56 sorties by jumbo, 747, and 27 were moved, after they were converted to cargo aircraft, they were moved to Syria.


“Facing clear evidence of peril, we cannot wait for the final proof -- the smoking gun -- that could come in the form of a mushroom cloud.” George W Bush.

We went into Iraq because the White House latched on to insufficient and contested intel of a nuclear weapons program in Iraq (the yellowcake and the aluminum tubes). It wasn’t about some rusted old artillery rounds with chemical weapons in them.


The CIA was very skeptical about the WMD story and there were lots of leaks that made that clear.


Seriously, I remember the Bush admin going after the wife of a CIA operative by leaking her identity after he spoke out about the war intel being bullshit. As someone who was following the Iraq war from the left side and pretty disgusted by it it definitely seemed like it was being pushed hardest by the GOP with anti-war information coming out of the CIA or even military. Granted leakers don't represent the opinions of an agency but this narrative that the CIA was the real villain (not that they aren't) that hoodwinked the poor GOP strikes me revisionist whitewashing.


I feel that that could've been an honest mistake too.

The intelligence networks there were weak, and if people were talking about it, they may have assumed wrongly that there was something there.

Politicians hunting for excuses to do what they already want to do though, is definitely a thing.


In the run-up to the second Iraq war there were a steady trickle of articles documenting the corruption of the intelligence process.


>Politicians hunting for excuses to do what they already want to do though, is definitely a thing.

Just to be clear: The people in charge are the CIA, not GWB. GWB was simply the right useful idiot at the right time in the right place.


That is very literally the opposite of what actually happened.

I don’t know where you are getting your information from but it’s absolutely incorrect.

It was Cheney specifically who was relying on Chalabi whom the CIA had repeatedly dismissed as a fabricator which is what was used as evidence.


Here’s an actual account from someone in the room that lays out the entire situation. https://youtu.be/5iNrGhmr5p0


> I feel that that could've been an honest mistake too.

There were a lot of indications that it was wrong even at the time, like the inspectors’ reports. We knew about the unreliability of the dodgy dossier and how baseless Khidir Hamza was. The satellite evidence was sketchy and the rest was contradictory. Al-Qaeda was also not there and we also knew that. Let’s not rewrite history: there is no certainty in intelligence, but anyone not in the CIA’s pocket knew it was most likely wrong, a far cry from what you need to legitimately attack a country.


Everyone is a Bayesian these days; it's become so fashionable to throw "priors" around like it means anything.


My prior includes neither agency can provide genetic analysis which would be the easiest way to convince a professor of virology that this theory has any merit.


Why would you think that?

It's obviously false if you just think about it, but you can also do some searching if you need some authority to tell you.


What about food addicts? It’s well understood that drive negative health outcomes and costs and are under the control of anyone with a decent income. Want ozempic to treat your diabetes? Submit your grocery store purchase history for analysis.


> Submit your grocery store purchase history for analysis.

why not? when you file for unemployment, you need to prove that you're looking for a job. if you want weight lose drugs that cost $1k+/month, you should show proof you aren't being a glutton. we have the technology, just not the political will.


>if you want weight lose drugs that cost $1k+/month, you should show proof you aren't being a glutton.

This makes as much sense as "if you want anti-depressants, you have to prove you aren't being sad".


I mean, there's a case to be made there. More often than not, anti-depressants are the first option given when someone is presenting those symptoms. There is little to no effort to address the root cause. It should be a last resort. Sadly young people, esp young girls, are being given these drugs like candy. It should be medical malpractice.


Do you know how those weight loss drugs work? They reduce your appetite. They're literally designed to "fix" the problem of "being a glutton." They don't magically burn more calories or whatever you think they do, they just make you eat less.


>The Secret Service told 404 Media in an email last week it is no longer using the tool.

Given that parsing non-denial-denials is journalism 101, I wonder at 404’s studious incuriosity about the Secret Service statement. Here are some questions I would ask the Secret Service on the record if this was my story.

1. Does the Secret Service use other tools, partners or methods to collect location data on Americans without establishing probable cause and obtaining a warrant?

2. Does the secret service collect the location data of all Americans, or does it target certain groups in particular? If the latter, how does the service decide who to target?

3. What other crimes become non-crimes if the private company hired to commit them gets the victim to check a box labeled “I agree to the terms of service” prior to watching a funny cat video?

4. Hypothetically speaking, is it now legal for me to start the “uber for loansharking” if my terms of service indicate that the penalty for late payment is kneecapping by non-employee gig muscle?

5. Can the secret service identify my source for this story by determining who i’ve been meeting for lunch at the Holiday Inn every Friday for the past two months? If so will your wife be in a lot of trouble?


> if my terms of service indicate that the penalty for late payment is kneecapping by non-employee gig muscle?

Why stop there? If ToS overrides the 4th Amendment, why not the 13th?


I was one of those people. Or months at least along with a group of my high school friends. Most of the infocom games took between a few weeks to a few months of obsessive game play to get through & we played them all.


Long term, I wonder if this destroys the Supreme Court. I see no reason why a future liberal majority would feel bound by any conservative precedent in the future. Replace respect for precedent with whatever position wins a majority and the incentive to pack the court seems irresistible.


And this would be true for any activist court. To me, the combination of a flaccid Congress plus activist court implies an era of disposable precedents.


That seems likely. We already see it in the executive, with sweeping policy changes every time the office changes parties. Seems to be what we want, however, collectively.


Seems like we're evolving from common to civil law, probably for the better in the long run.


I tend to agree that civil law should be better over the long term, but I don’t see this Supreme Court letting that happen. They pretend to be deferent to congress when congress is ineffective or on their side, but the script can be easily flipped or used both ways at the same time like they do with states rights. But ultimately they would not let themselves be constrained by a hostile congress.


This Court seems to be reducing both executive and judicial power, pushing it back to the legislature where it belongs.

But we now have worse representation in the United States than in Communist China, we're an extreme outlier among every OECD country, and this Congress is close to doing literally nothing:

https://en.wikipedia.org/wiki/List_of_acts_of_the_118th_Unit...

So the result will be reducing federal power itself, kicking it back to the States. You know, laboratories of democracy. And now seemingly autocracy and theocracy as well...


The pendulum swings. For decades we had an activist progressive court and now we have an activist conservative court.


There was a 7-2 liberal majority during the 1970s. They didn't feel bound by precedent either. That's how we got, for example, Roe v. Wade. (No, there was no precedent for "a penumbra" of privacy giving a right to abortion in any previous court decisions. And whether you like the decision is orthogonal to whether the court was making stuff up completely outside the realm of precedent.)

Conservatives aren't doing something that liberals have not done. Liberals will probably do it again when they have the chance. And so will conservatives.

You don't have to like it, either because it goes against what you want or because you don't think decisions should be made like that. But don't think that this hasn't happened before.


> There was a 7-2 liberal majority during the 1970s.

Can you break this down? I'm looking at the Martin-Quinn graph[1] for the 70s and I'm seeing a pretty centrist, if not majority conservative, slant for that decade.

[1] https://en.wikipedia.org/wiki/Martin%E2%80%93Quinn_score


[flagged]


Remind me again which side is the antisemitic one nowadays? Was it the far left or the far right?


How do you imagine a liberal majority would come about within the next few decades? This was engineered over decades and now the conservatives have all the marbles; that's why they feel so free to rule how they've always wanted.


I imagine you’d need circumstances similar to those that nearly resulted in the Judicial Procedures Reform Bill of 1937, which would have granted Roosevelt the ability to appoint 6 additional Supreme Court Justices. Namely:

- National crisis unifying popular support for liberal legislation. - Liberal control of the executive and legislative branches. - A series of supreme court rulings that effectively thwart a popular liberal agenda.

I have no idea if this is likely; however it nearly happened less than a century ago during a period with noticeable parallels to our circumstances today.


Privately-owned ebikes are enormously popular in Chicago and surrounding suburbs fwiw.


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