I'm surprised, because you don't often hear that particular criticism of 2C-B.
Mostly, people complain about nausea, or the fact that it burns very painfully when people insuflate it
Purity and accurate dosage is a function of your vendor. Buying 2C-B pills will be more dangerous, they are notoriously underdosed and should ideally be sent to a lab first, but at the very least spot-checked with a reagent test kit.
Duration is a subjective preference, I feel. LSD is nice, I like it very much, but I can understand than 12 hours uninterrupted is not something everyone can allocate in their schedule.
Yep, I spared the details regarding nausea but the contents of my stomach were definitely emptied once or twice. As far as I remember it wasn't anything special and the additional side effects and risk you describe make it just not worth it in my opinion.
That's fair enough. I did hear it repeated a lot that 2C-B's dosage curve seems to be particularly steep and non-linear. I don't know that it's been studied very scientifically, but reportedly the difference between 40 and 50mg is much bigger than the difference between 20 and 30.
I stick to low dosages, partly to avoid nausea and partly because I like to be somewhat cautious with this delicate biological machinery I don't understand.
For me it's also something I can take a small dose of occasionally when I have a big night out, if I'd like to sleep early, or if I'd like more stimulation and less headspace.
LSD I use for long introspective trips, physically by myself so that I can tune in and out of online social interactions depending on how I feel.
I feel like 2C-B is a nice option to have for different settings. Since I don't very much experience the downsides it's worth it for me, but I can definitely acknowledge the downsides =)
Snort it (hurts really bad for 5-10 minutes, afterwards okay, redosing takes its toll though...) can help with the nausea. I make a solution so that I can use a nose spray to dispense about 2-5mg per pump. Then I can redose every 15 minutes until I get to a dosage I enjoy.
Ketamine (as its S-isomer) is approved by the FDA for treatment-resistant depression.
Note that while the evidence for Ketamine's antidepressant effect is actually strong, that does not mean you should get into the habit of snorting a gram of special K a day.
Ketamine abuse is known to cause serious, practical damage to the GI tract, the urinary system, the liver, and the brain.
Although a ketamine treatment plan for depression requires subanesthetic doses once a week at first, and then once every two weeks. It's also habit forming enough that it's difficult to not overdo it due to its effects on dopamine. It has some definite utility, but it's the kind of medication that is hard to use alone
Experimentally, it works. There are theories (google will give you a couple vaguely plausible mechanisms), but it's too early to say. And it's likely that the antidepressive effect of ketamine has nothing to do with its NMDA antagonism, given that other NMDA receptor antagonists do not work as antidepressives.
Neuroscience theory lags far behind applied psychiatry, so all know is people whose depression resists normal treatment now have another very promising option, with a very different mechanism from normal antidepression treatment.
Dissociatives are the most under-appreciated class of drugs.
Mechanisms of action are difficult to be objective about. It is a lot more complicated than dopamine and serotonin regulation and uptake, receptors and antagonists.
Today was pleasant, despite every reason not to be. It's like the "hope" qualia.
Thank you, this is what I was looking for. So - on biochemistry level we don’t know why it works. But somehow, controlled temporary disassociation seems to… interrupt negative ideation?
If the buyers are engineers that understand the concept of storage space measured in bytes, this 'estimate' does not help them. If they don't, it only serves to mislead.
The fact that buyers may talk to salespeople is really not an excuse for the deceptive behavior.
"well, in our restaurant medium rare means well done and rare means medium rare, but that's okay our customers are well-paid professionals, they'll talk to waiters to get a more accurate picture"
Tangent: That's how most restaurants operate, because most people don't know what the words mean and get upset when they ask for "rare" and get what they asked for.
Clothing manufactures also lie about the waist measurements of pants. (Go measure yours and see.)
Taking away the option of perpetual licenses is an interesting business decision. Jetbrains makes the subscription model work, but they also do give you a permanent license to older versions after 1 year of subscription (which is a great incentive to keep people renewing!)
Historically, IDA Pro's sales and licensing has always been a bit of a headache for customers. I could understand that the OPEX model makes it easier for some companies to keep renewing.
That just goes to show that I'm not their target market. Even if IDA had a pay-what-you-want option, the 10-20 I'd be willing to pay per month while using a leaked version is clearly completely negligible compared to what they normally charge.
And I'm happy to just use Ghidra instead of bothering with an IDA leak, so I suspect this announcement might simplify things for their existing corp users, but it'll probably not do a great job of expanding the home userbase.
You do realize that is a win from a customer service and reputation perspective? Jetbrains listened to their customers, and amended their model. That is the kind of responsiveness I would appreciate in a vendor, especially if it's a vendor that produces tools that I enjoy using or help me make money.
Anyone who has worked on customer facing projects or tools know there is always overwhelmingly negative feedback to billing increases. What is less common is vendors being responsive to that in a way that is actually beneficial to customers. That is doubly the case when you are dealing with high quality, specialty tools that have free or open source competitors that are good enough to get by, but not great (Adobe suite vs various free and open tools, for example).
Screen readers work great, for me it's my phone. On my desktop I'd be getting distracted and bored in about two paragraphs. Even if I try to come back to the article, there's invariable 3 other things that I'm switching between.
On my phone I've read 250k word books cover to cover, same books I could never read on a PC. Attention is weird like that.
Another trick is getting your dopamine* externally. There's an association between ADHD and substance abuse, and I can see why. Pharmacology is a cheat code: a few hours of infinite motivation, will power, and attention.
Unfortunately, when people start needing a substance just to feel normal, that is the definition of an addiction.
(* More complicated than just Dopamine or Serotonin, both seem to play a role. Medecine has not solved this one yet.)
> Unfortunately, when people start needing a substance just to feel normal, that is the definition of an addiction.
Disagree. What is 'normal'?
A better definition for addiction is the brain no longer produces the neurotransmitter without the presence of the drug (or is doing so at a highly diminished rate). There's no evidence that such occurs with the amounts prescribed for adhd.
For that matter, people needing an external source of a substance to feel normal is unavoidably part of being an organism. We need water, or we wont feel normal. We need vitamins -- and plenty of people have vitamin deficiencies, are they addicted to said vitamins?
That's a tough question to answer, and I think people should make that decision for themselves, with all the information they have about their particular situation.
Negative side effects of note with usual ADHD medication (amphetamine salts) include increased cardiovascular load, development of a tolerance (you need higher doses to achieve the same effect). Sometimes amphetamines induce small changes in personality, rarely full blown psychosis (this has happened at therapeutic doses!).
In general you should apply the same sort of risk-benefit analysis we use for every other drug. If you don't experience any side effects so strong you want to stop, and you believe you're aware of the risks, great.
If you're taking them without a script, I'd advise you to find a steady-state dose that works for you and stick to it. Don't let yourself increase the frequency or the dose without a conscious decision. That's how many people have spiraled.
Finally, I think it's important to have a lot of respect for psychoactive chemicals. Nature doesn't care very much for human overconfidence. If you start being careless, chemistry will do what chemistry does.
Pony Town is a classic! It's crazy how popular it is for how sparse the featureset is, I guess it's a testament to the value proposition of sites like this.
You should honestly ask yourself why this is not a popular comment.
If you start by assuming everyone else is arguing in bad faith ("people who just wanna be seen looking like they care"), then it's easy to dismiss any criticism, and it'll be hard for you to prove yourself wrong.
If you never try to know when you're wrong, you could end up stuck with wrong beliefs for the rest of your life.
I have no stake in your life, but I'd recommend against that.
Unflattering observations are fine, if they're based on solid evidence or at least some sort of logical process of determination. You do neither of those things and just throw around your personal opinion as gospel. It's unnecessary and doesn't add anything of value to the conversation.
With the rise of online shopping, the big suppliers are a lot more visible than they were before. I like to read stories on forums sometimes.
It turns out there are more than a couple LSD labs, some having a bigger internet presence than others.
Suppliers will not sell directly to random people, but as it turns out their approved resellers are happy to offer spoonfuls of LSD in powder form to anyone who asks!
I love things that work well, and I think that despite the world of computing being criminally suboptimal, we seem to be making progress! Slowly. And I'm grateful for it.
The world is a surprising beast of incredible complexity, and I'm in love with it.
I agree that success is silent, but I don't think that means people don't appreciate things that work well. It's just that expressing that appreciation almost always sounds shallow. Of course it works well, that's obvious. Why bring attention to things we've solved, things we take for granted.
It's easy to notice things that don't work and use that observation as a tool to improve. It's much harder to separate the things that worked well by accident from the truly good designs.
Praise is a much more fraught art than criticism. You will see more of the latter.
Purity and accurate dosage is a function of your vendor. Buying 2C-B pills will be more dangerous, they are notoriously underdosed and should ideally be sent to a lab first, but at the very least spot-checked with a reagent test kit.
Duration is a subjective preference, I feel. LSD is nice, I like it very much, but I can understand than 12 hours uninterrupted is not something everyone can allocate in their schedule.