> simultaneously extremely similar to and extremely different
yeah, I don't understand the change tbh.
It's said Eric Heisserer spent years and years on the screenplay so I'm assuming he couldn't sell the original version. But it's a bit like making fight club and removing the big reveal. It ends up feeling the same, but not having the same impact and meaning almost the opposite.
> The best reason to take multiple life extension supplements is to hedge our bets, because we really don’t know which of them are effective in humans.
And earlier:
> Personally, I take large doses of rapamycin 2 days a week, 8 weeks per year. For personalized recommendations, you can consult your favorite life extension doc.
I recently saw a patient with overwhelming MRSA sepsis with multiple foci of infection including epidural abscess (around the spinal cord), and meningitis. This person was taking rapamycin presumably for "life extension" purposes. Almost certainly the immunosuppression from the rapamycin made the infection much worse.
I'd be very wary of taking an immunosuppressive drug as an otherwise healthy person for theoretical life extension properties.
Rapamycin modulates the immune system. I get that he's probably consulting a doctor but can you imagine taking this risk during a pandemic or even in older age? It makes me uncomfortable to play around with these very powerful drugs.
The dosage for longevity is supposed to be low enough that this risk is minimized. Lots of things you do modulate your immune system (including e.g. exercise). It's a risk/reward thing, every time you get into your car you're also taking a longevity risk.
I think there are some proper human trials happening but the jury is still out.
People are still getting nerve damage from too much vitamin B6 in energy drinks and vitamin supplements, and that's a well known and widely taken vitamin. The idea that you can take experimental drugs your entire life at little risk is optimistic.
Surprisingly, many people seem to think that pushing a few random pills into a machine optimized over some million years of evolution will tune it so it works better. Go figure...
Yes, although even for modern medicine curative and preventative strategies are very distinct. Sure, they'll give you pills to compensate for a problem you already have. But there are few meds that protect you against stuff you'll maybe catch in the future. Vaccines and antibiotics are obvious examples, but I'm not aware of many others. The rest of preventative strategies overwhelmingly consists in correcting deficits or excesses (calories, vitamins, sleep, exercise etc.)
Never put 100% of your savings into a single slot machine. Take 10% of your savings to 10 different casinos and distribute them to 10 slot machines in each, in order to hedge.
Oh there's plenty of people selling "side effect free" life extension supplements. But there's another name for side effect free medication: effect free.
Not doubting all this, but the possum thing is interesting.
They were in southern ontario in my youth in essex county ( late 80s ). And google says they were reports as far back as the 60s of scattered sightings.
You seem to be suggesting he's writing from a place of not knowing about the benefits of one-on-one learning and the "two sigma problem" when this is something he frequently writes about.
You can do that manually. Say for example you learn integration by trig sub today and you do 30 problems from a book. Next week you do some more trig sub problems. Then 2-3 weeks after that you do some trig sub problems and then in a few months you do some. You can do spaced rep manually. Is mathacademy more efficient? I don't know. It's too early to say. But what I do know is millions of people have learned mathematics with books, pen and paper for hundreds of years.
Absolutely. You can spend time on figuring out what to do next, and how, and how to do spaced repetition for the material and test yourself effectively. There are aspects you'll do better than a set curriculum because you understand yourself, and there are mistakes you'll make because misunderstandings and errors.
Or you can pay an expert to do that for you, and just use the time on learning.
I think it is worth it if it stops the bad policy of supply management that harms everyone except a small group of farmers. Quebec and to a lesser extent Ontario being full of wankers is why we have supply management when it is obviously stupid, not who will be hurt by tariffs (although they will hurt from the tariffs and they have earned it, unlike the rest of us who are hurt by the same tariffs)
I would think naturally occurring lithium in some people's water would give pretty good control conditions to do a wide study of this effect on Alzheimers as well?
The literature search identified 415 articles; of these, 15 ecological studies were included in the synthesis. The random-effects meta-analysis showed a consistent protective (or inverse) association between lithium levels/concentration in publicly available drinking water and total (pooled β = −0.27, 95% CI −0.47 to −0.08; P = 0.006, I2 = 83.3%), male (pooled β = −0.26, 95% CI −0.56 to 0.03; P = 0.08, I2 = 91.9%) and female (pooled β = −0.13, 95% CI −0.24 to −0.02; P = 0.03, I2 = 28.5%) suicide mortality rates. A similar protective association was observed in the six studies included in the narrative synthesis, and subgroup meta-analyses based on the higher/lower suicide mortality rates and lithium levels/concentration.
Is advising people to wear sunscreen and not speed also nannying? If the government ultimately bears the costs of poor health of citizens, why shouldnt they embark on public health interventions to lower those costs.
Wow, small world, I just made a podcast episode about the dangers of turning your brain off when using Agentic coding solution and referenced the whispering earring as my metaphor.
I feel like if you use the agentic tools to become more ambitious the you'll probably be fine. But if you just work at a feature factory where you crank out things as fast as you can AI coding is going to eat your brain.
Isn't this just some loops and joining with some changes in prompts?
Can't you write this in a for loop calling the open AI API directly?
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