yes shopify runs on truffleruby. It is the fastest ruby VM by far and can seamlessly call state of the art Java libraries.
GraalVM is the VM to rule them all and unify currently incompatible billions of dollars libraries ecosystems.
Despite being the computer science breakthrough of the decade, people are not getting it yet.
An open question would be wether the baseline inflammation level could be lowered if we implemented a periodic but rarer higher inflammatory level.
So a ~flatline vs a sinusoid. It could be pharmacologically simulated.
Sounds like exercise or maybe a dry sauna would be a cost effective non pharmaceutical way, short term increase in inflammation that results in a long term decrease in inflammation. Same thing with injuries and fractures but that’s more unrelated.
Hormesis and the hygiene hypothesis suggest that "working out" can be good for the immune system too. Unfortunately variolation has become a difficult topic.
I don't think doing exercise trigger an inflammatory (immune) response although I might be wrong. Either way your point stand regarding its paradoxical effect on oxidative stress.
Exercise does trigger inflammation through a variety of mechanisms (eg.: increased tissue perfusion and diapedesis, oxidative stress, tissue damage...).
However it also releases endocannabinoids, which are anti-inflammatory, and causes a host of metabolic changes which are also anti-inflammatory.
The overall effect of exercise is to increase inflammation acutely, and to decrease it chronically. Regular physical exercise is overall more modulatory than inflammatory.
Somewhat related to your idea, they seem to have some success with parasitic therapy with things like Crone. Introduce a "harmless" parasite (worm) and the body's immunesystem to trigger it. Not sure how long they keep it in the body, seems to be mostly for a longer time.
I don't think I've seen any serious suggestions that inflammation per se causes beneficial adaptations. Rather, <some activity> imposes a stress and the recovery/adaption process is mediated by inflammation, i.e. the why of the inflammation is important.
I don't understand,the yuzu (switch) emulator has excellent performance and correctness. It perfectly emulate a modern ARM cpus at multiple GHz and properly emulate the Tegra Nvidia GPU.
Why would emulating x86 be so much harder, especially since you can actually use the host x86 cpu... via hardware hyoervisors e.g.
https://github.com/intel/haxm
Yuzu uses Unicorn, which uses QEMU code for functional, but not cycle accurate CPU emulation. Most software these days don't depend on the exact behavior of the hardware, even on Nintendo Switch, and the emulator can also use application-specific patches to make up for the difference.
86Box is not entirely cycle accurate, but much more accurate than QEMU, so no patches are required.
gem5 is on the other end of the spectrum, it can emulate hardware very accurately, but very slowly.
Well that makes pcem and x86box very niche then.. What should people actually use for emulating a recent x86 cpu like found on the PS4/PS5/xbox serie x and get good performance? Because this is where the human resources should be allocated, for enabling the support of hundreds of video games including major console exclusives
Should does not equal must. Wanting a better world with less suffering and more joy is not the same thing as imposing this world by force. A thought that should have occured to you.
Emulating the CPU of those newer consoles would be quite slow. The practical approach would be a translation layer like Wine with many application-specific patches. The translation layer for the graphics would involve a lot of reverse engineering.
MAOIs are not necessarily more dangerous, they just need a low tyramine diet which is easily doable. Moreover you can significantly lower this need with a concommitant NRI.
transdermal (emsam) or selective mao-a or b don't even need a diet and are safer than SSRIs (no PSSD)
> Anti-depressants, if dosed and chosen properly, have basically no side effects
WTF is that bullshit ?
SSRIs destroy libido and possibly permanently (see r/pssd)
MAOIs have many side effects
NRIs are not effective
NDRIs can cause tinnitus.
Stims are cardiotoxic and usually not prescribed for depression.
TCAs are not an action mechanism and therefore fall in the above categories.
Atypical mechanisms are not better either.
The only ones with low side effects either cause some sedation (mirtazapine, agomelatine) or have dubious effectiveness.
The only one that stands out is moclobemide and maybe bifemelane. The latter is only available in japan. The former has low efficacy.
hence for someone that don't want side effects, only moclobemide make sense, or ultra atypical stuff that has probably low efficacy. One of the only atypical that might be potent is SAM-e but who wants to play with his DNA methylation ?
9 mebc is phototoxic unfortunately as it is very promising otherwise.
edit: it's true though that testosterone is apparently as effective as SSRIs and with less side effects.
What should be said though is that there are some great anxiolytic out there, it's just that no one knows them, e.g opipramol, emoxypine, etifoxine
This is the reason why some people suggest not to listening to any comments. A lot of stuff here are factually incorrect:
1) MAOIs are safe, and Parnate specifically is extremely effective. However, requires a special diet to adhere.
2) Stimulants ARE prescribed very frequently to augment antidepressants in difficult cases, especially in people with serious illness.
3) Moclobemide has every effect of an MAOI in effective dosages, including diet restriction. There are no effective drugs without side effects. Moclobemide is not thought to be particularly effective(mostly because on-label dosage is far too low), there is a reason why it's used infrequently.
4) Etifoxine might be great for some, but it has significant risks of liver injury. There is a reason why Valium is still one of the most common anxiolytics prescribed worldwide.
I mean, theoretically if you can get the model weights onto disk then you should be able to do the computation - but it might takes days or months on commodity hardware. It would also require creating a system that can do this and I doubt there is much demand.
