My ultra qualified friend who is a lead at a fortune 500 company has only had 2 leads in 11 despite being probably in the top 3 best available candidates for all 11 applications. So yeah, I don't think many tech companies are actually hiring.
I have had very high (3x upper limit normal or more) levels of fecal secretory IgA ever since I took antibiotics in 2014. Also numerous health issues and allergies that developed ever since. Nothing has seemed to really work. I have to take antihistamines just to not feel like I need to go to the emergency room from reacting to things all the time. Pretty tilting since I developed these problems at such a young age. It felt like it completely robbed my life from me. And I'm fairly certain the antibiotics did it because the problems literally just developed in the months following, and some almost immediately after taking them. One of the drugs, ciprofloxacin, seemed to cause severe connective tissue problems that are actually permanent. It is over 10 years later and I still extremely readily tear tendons and ligaments, when before I took them I never once had any problems with any of my tendons or ligaments no matter what I did and no matter how often I did it. My first tendon issues ever were the month after taking it.
Even if you never got a SIBO diagnosis, look into the mBiota elemental diet course they offer. 2 weeks of it has been proven to normalize the gut microbiome for SIBO patients (methane & hydrogen).
I also had a very negative reaction to ciprofloxacin and later moxifloxacin (I took them for different infections). In any case, I haven’t suffered tendon issues just neurological effects (hard to describe how my cognition changed but I was simply unable to sleep for several days until I stopped the medication prematurely).
Did you bother taking or trying some good probiotics and maybe prebiotics? How about L-glutamine, collagen hydrolysate, vitamin C, MSM, glucosamine, chondroitin? Also quercetin.
There is a newssurvey software that you can use to do some automated survey of what's out there (if you don't want to do it manually).
My experience with antibiotics has been the opposite, that they have saved me more times than one, but then I never used ciprofloxacin.
Probiotic products can be very diverse in their coverage and usefulness. The one I like is Epic Pro 25.
In any case, how about folate as Quatrefolic? It has shown relevance in a related issue such as Ehlers-danlos affecting connective tissue. It is unclear if your homocysteine level is normal or not, but if it's not, it can probably be resolved by various B vitamins in good forms and doses.
In any case, I doubt you have tried newssurvey software to do a survey on:
1. What causes ciprofloxacin (or its class fluoroquinolones) to harm connective tissues?
2. What is its resolutions, whether pharmacological or nutritional or via supplements, or anything else?
> 1. What causes ciprofloxacin (or its class fluoroquinolones) to harm connective tissues?
mTOR Signaling
Fluoroquinolones are known to affect the mTOR (mammalian target of rapamycin) pathway, which is critical for protein synthesis, cell growth, and tissue repair. mTOR integrates signals from nutrients, growth factors, and energy status to regulate cellular anabolic processes like collagen synthesis and fibroblast activity. However, fluoroquinolones can induce oxidative stress and mitochondrial dysfunction, which may disrupt normal mTOR signaling. This interference can impair the normal anabolic functions of mTOR, potentially leading to diminished protein synthesis and weakened connective tissue repair.
Mitochondrial Dysfunction
Fluoroquinolones can damage mitochondrial DNA, which may reduce ATP production and impair cellular energy homeostasis. Since mTOR activity is energy-dependent, reduced ATP availability could downregulate mTOR signaling, inhibiting processes like fibroblast proliferation and collagen synthesis. This could explain the tendinopathy and cartilage damage sometimes associated with fluoroquinolone use.
Collagen Synthesis and Matrix Remodeling
The anabolic processes that support collagen production and extracellular matrix (ECM) remodeling are crucial for connective tissue integrity. Fluoroquinolones have been observed to impair collagen synthesis by disrupting the fibroblast function, and this may be due to their impact on the energy-intensive processes governed by mTOR.
Fluoroquinolones have also been reported to cause central nervous system (CNS) effects, including anxiety, tremors, and other neurological symptoms, suggesting an impact on adrenergic pathways. This dysregulation could interfere with normal stress adaptation mechanisms, including the modulation of inflammatory and regenerative processes in connective tissues.
Connective tissue healing depends on the body’s capacity to manage energy demands and stress responses during recovery. Fluoroquinolones can impair mitochondrial function and create an energy deficit at the cellular level, reducing the ability of fibroblasts to engage in critical processes like collagen synthesis and ECM remodeling. The systemic impact on both dopaminergic and adrenergic systems can further weaken the body’s ability to manage stress and energy during recovery, exacerbating the negative effects on tissue repair.
Fibroblasts and Collagen Production
Fibroblasts are the key cells responsible for producing collagen in connective tissues. Under conditions of oxidative stress and energy depletion, fibroblasts may enter a senescent state, reducing their capacity for collagen synthesis and matrix repair. This can lead to weakened connective tissue and increased susceptibility to injuries like tendon ruptures, which have been reported with fluoroquinolone use.
Collagen and Tendon Health
Fluoroquinolone-induced dysregulation of cell signaling, energy metabolism, and oxidative stress management all converge on a critical issue: the weakening of collagen structure and connective tissue integrity. This has been particularly evident in the association between fluoroquinolones and tendinopathy or tendon rupture, likely linked to the disruption of collagen synthesis, the downregulation of mTOR, and the stress on connective tissue cells such as fibroblasts.
Yes, 100%. But apparently, there are cases where fluoroquinolones cause long-lasting oxidative damage or mitochondrial dysfunction. The recovery of mTOR signaling then may be slower.
Even after the cessation of fluoroquinolones, prolonged oxidative stress can lead to chronic inflammation and collagen synthesis may remain impaired.
Ongoing mitochondrial damage can reduce the cell's capacity to respond to anabolic signals, potentially leading to prolonged weakness in connective tissue and a higher risk of tendon damage. The slow recovery of mitochondrial function may lead to extended mTOR inhibition in tissues like tendons and ligaments.
This bit is especially interesting:
Fluoroquinolones also impact dopaminergic and adrenergic systems, which regulate the body's stress response (via dopamine and norepinephrine). This disruption can affect how the body handles both acute and chronic stress, with potential long-term changes in the hypothalamic-pituitary-adrenal (HPA) axis. Dysregulation in the HPA axis could affect cortisol production, impacting inflammation, immune function, and tissue repair over an extended period.
Long-term impacts and the systemic nature of chronic inflammation, mitochondrial damage, and persistent oxidative stress can lead to structural or functional deficits in tissues that were secondarily affected during the acute phase of stress and disruption, which can manifest as persistent dysfunction, pain, or delayed healing.
If premature senescence is the mechanism, then quercetin, fisetin, and urolithin A are in general extremely relevant to fight it. Personally, I make sure to take collagen hydrolysate daily to assist the body.
Agree. Quercetin did help with recovery, but so did eating the equivalent amount of foods that contain it: Red Onions, Red Grapes, Berries, dark green veggies. Rather a lot of those of course, about 1 to 1.5 kg combined. I remember the clinically effective dose to fight colds and so on to be 500mg, but my body dumped quite a lot of that into the toilet, so I halved the dose on another occasion and the effect was the same and I recovered quicker that when not taking it. But again, those foods in adequately high amounts did enough, probably because they also give energy, vitamins, minerals as well.
Agree on the collagen as well, especially for recovery after injuries and after surgery.
Have you tried a 3 to 6 month long retreat at an organic farm with no supps and only the meds that you really need? You can bring your gear and build games there, too.
I wanted to dive into the production of all the different supps for a while but intuition tells me it'll end up in some reverse confirmation bias aka "job security and esoterically enhanced anti-pla-no-cebo thinking" ... and that kills my mood.
If it's not AS then no idea - I assume they did the gene testing and whatnot.
Lot of people swear by this odd Japanese fermented food called Natto - might help. It's basically just soybeans. Uses a very unique bacteria though. Most Asian markets have it
Not directly, anyways. Google still gets to track which pages you visited and what you searched while trying to answer questions you interact with on the site.
No, Google does not track your activity on third-party sites, or the pages you visit there, or the data you enter there, just because you authenticated with your Google account.
Yeah I'm open to the idea of a site like this, but I have a major concern that this is like the gold mine of data for product designers and marketing people to help sell you something that dosnt really help.
